Single Pot Processing _ Combining best of wet granulation technologies
Powder processing technology has developed tremendously over century. When it comes to pharmaceutical industry however, precision required expands it beyond world of textbook formulas. When it comes to granulation in tablet manufacturing, available wet granulation process with multi-unit, multistage batch processes dominates industry. Complexity of these stages requires more human intervention which in turn demands stringent monitoring and control of process at processes as well as material handling. Some adapt to material handling using vacuum making process semi-automatic. None the less possibility of doing all in single go is lucrative. Single pot process technology has been developed exactly for this purpose.
Concept of single pot processing has been available since 80’s. So it is not completely unknown. However, it became adaptable only after developments in technology in last decade. Development of NCEs (New Chemical Entities) with high demand of containment in processing both from perspective of product safety as well as operator safety rejuvenated interest of pharmaceutical experts in this prospect. Yet, there are inherent barriers in Pharmaceutical industry when it comes to development and adaptation of new science or technology. Current wait for COVID-19 vaccine development was harsh reminder of fact. While other industries can easily integrate latest developments, Pharmaceutical industry has its scientific methodology to approve and apply new techniques while producing proven drugs qualified with older techniques.
In case of wet granulation, well accepted bottom driven High Shear Wet Granulation is the established technology to deliver desired high density. Using fluid bed processors or top driven processors which give low density pharmaceutical ingredients completely altering drug delivery properties of your tablet is certainly not immediate and acceptable alternative. Knowing this key hurdle in acceptance of Single Pot Processing, experts at GENESIS developed AI Single Pot Processor based on well-established bottom driven technology. Simplicity of this innovation combines best of both worlds in Single Pot Processing making Tech-transfer easy for pharmacists. Not to mention, with advancements in technology, PAT compliance has become integral part of Single Pot processing. Empowered with such features, Single Pot processing reproducibility and scalability becomes much efficient for developers and users in pharmaceutical industry.
Other desirable characteristics of Single Pot Processing would be very obvious reduction of multiple units, containment, efficient use of costly pharma-space, less demanding cleaning SOP, considerable reduction in operating and future ready plant.
For more information of Single Pot Processing, Genesis experts are always ready to assist you. Please share your queries at info@genesis-process.com
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